Journal
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Volume 60, Issue 5, Pages 1155-1158Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkm338
Keywords
macrolide resistance; pneumococcus; protein synthesis
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Objectives: To compare the effects of subinhibitory concentrations of amoxicillin, ceftriaxone, azithromycin, clarithromycin, erythromycin, telithromycin, clindamycin, ciprofloxacin, moxifloxacin, tobramycin and doxycycline on pneumolysin production by a macrolide-susceptible strain and two macrolide-resistant strains [erm(B) or mef(A)] of Streptococcus pneumoniae. Methods: Pneumolysin was assayed using a functional procedure based on the influx of Ca2+ into human neutrophils. Results: Only the macrolides/macrolide-like agents caused significant attenuation of the production of pneumolysin, which was evident with all three strains of the pneumococcus. Conclusions: Macrolides, at sub-MICs, but not other classes of antibiotic, subvert the production of pneumolysin, even in the presence of (and irrespective of the mechanism of) macrolide resistance in S. pneumoniae.
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