Journal
EXPERIMENTAL PARASITOLOGY
Volume 117, Issue 3, Pages 275-283Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2007.06.003
Keywords
Schistosoma; glycoprotein; carbohydrate; host-parasite interaction; immunomodulation; antigen; glycome; glycan; lectin; CAA, circulating anodic antigen; CCA, circulating cathodic antigen; CD, cluster of differentiation; DC, dendritic cell; DC-SIGN, dendritic cell-specific intercellular adhesion molecule-grabbing non-integrin; HILIC, hydrophobic interaction liquid chromatography; KLH, keyhole limpet hemocyanin; LacNAc, N-acetyllactosamine; LC, liquid chromatography; Le(X), Lewis X; mAb, monoclonal antibody; MALDt-TOF, matrix assisted laser desorption ionisation-time of flight; MGL, macrophage galactose-binding lectin; MR, mannose receptor; MS, mass spectrometry; PNGase, peptide-N-glycosidase; SEA, soluble egg antigens; TLR, toll-like receptor
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Schistosome glycans and glycoconjugates play a prominent role in the parasite's biology, in particular in the interaction with the human host. A large amount of structural data regarding glycosylation of different schistosome life stages and glycoconjugate subsets has been collected in the last decade, but many significant gaps in our knowledge of the schistosomal glycome remain. Here we will present a concise review of the already available data guided by a selection of recently generated stage-specific glycan profiles, and discuss implications and prospects of glycomics studies of schistosomes. (C) 2007 Elsevier Inc. All rights reserved.
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