Journal
LANCET NEUROLOGY
Volume 6, Issue 11, Pages 1004-1014Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S1474-4422(07)70266-1
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Funding
- Medical Research Council [MC_U105579219, MC_U105559861, G9724461] Funding Source: Medline
- MRC [G9724461, MC_U105579219, MC_U105559861] Funding Source: UKRI
- Medical Research Council [MC_U105559861, G9724461, MC_U105579219] Funding Source: researchfish
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Semantic dementia (SD), one of the main clinical variants of frontotemporal dementia, presents a unique combination of clinical and imaging abnormalities. We describe the epidemiological, cognitive, and radiological features of SD. The distinctive and consistent neuropsychological deficits in this disorder have had a major effect on current conceptions of the organisation of semantic memory and its links to episodic memory, language, and perceptual processes. Structural (MRI) and functional (fluorodeoxyglucose-PET) studies in SD emphasise the role of the temporopolar and perirhinal cortices. Unlike other frontotemporal dementia syndromes, the neuropathological findings in SD are fairly predictable: most patients have ubiquitin-positive, tau-negative neuronal inclusions.
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