Journal
AMINO ACIDS
Volume 42, Issue 2-3, Pages 711-723Publisher
SPRINGER WIEN
DOI: 10.1007/s00726-011-0987-y
Keywords
Polyamines; Membrane transport; Permeases; DNA cloning; Vesicular transport
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Funding
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institutes of Health Research
- Cancer Research Society-Quebec
- National Institutes of Health (USA)
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Very limited molecular knowledge exists about the identity and protein components of the ubiquitous polyamine transporters found in animal cells. However, a number of reports have been published over the last 5 years on potential candidates for metazoan polyamine permeases. We review the available evidence on these putative polyamine permeases, as well as establish a useful A << identikit pictureA >> A of the general polyamine transport system, based on its properties as found in a wide spectrum of mammalian cells. Any molecular candidate encoding a putative A << generalA >> A polyamine permease should fit that provided portrait. The current models proposed for the mechanism of polyamine internalization in mammalian cells are also briefly reviewed.
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