Journal
BIOMATERIALS
Volume 28, Issue 31, Pages 4571-4580Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2007.06.036
Keywords
foreign body response; angiogenesis; inflammatory response; nitric oxide; xerogel; wound healing
Funding
- NIBIB NIH HHS [R01 EB000708-06A1, R01 EB000708-07, R01 EB000708, EB000708] Funding Source: Medline
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The tissue response to nitric oxide (NO)-releasing subcutaneous implants is presented. Model implants were created by coating silicone elastomer with diazeniumdiolate-modified xerogel polymers capable of releasing NO. The host tissue response to such implants was evaluated at 1, 3, and 6 weeks and compared to that of uncoated silicone elastomer blanks and xerogel-coated controls incapable of releasing NO. Delivery of NO (similar to 1.35 mu mol/cm(2) of implant surface area) reduced foreign body collagen capsule (scar tissue) thickness by > 50% compared to uncoated silicone elastomer after 3 weeks. The chronic inflammatory response at the tissue/implant interface was also reduced by >30% at NO-releasing implants after 3 and 6 weeks. Additionally, CD-31 immunohistochemical staining revealed similar to 77% more blood vessels in proximity to NO-releasing implants after I week compared to controls. These findings suggest that conferring NO release to subcutaneous implants may promote effective device integration into healthy vascularized tissue, diminish foreign body capsule formation, and improve the performance of indwelling medical devices that require constant mass transport of analytes (e.g., implantable sensors). (c) 2007 Elsevier Ltd. All rights reserved.
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