Journal
AMINO ACIDS
Volume 41, Issue 3, Pages 609-620Publisher
SPRINGER
DOI: 10.1007/s00726-011-0908-0
Keywords
Low molecular weight gelators; Pseudopeptides; Metal ions; Azelaic acid; Pseudoprolines
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Funding
- Ministero dell'Universita e della Ricerca Scientifica
- Universita di Bologna
- Fondazione del Monte di Bologna e di Ravenna
- Consorzio Inter-Universitario di Ricerca della Chimica dei Metalli nei Sistemi Biologici
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A small library of stereoisomeric pseudopeptides able to make gels in different solvents has been prepared and their attitude to make gels in the presence of several metal ions was evaluated. Four benzyl esters and four carboxylic acids, all containing a moiety of azelaic acid (a long chain dicarboxylic acid) coupled with four different pseudopeptide moieties sharing the same skeleton (a phenyl group one atom apart from the oxazolidin-2-one carboxylic group), were synthesized in solution, by standard coupling reaction. The tendency of these pseudopeptides to form gels was evaluated using the inversion test of 10 mM solutions of pure compounds and of stoichiometric mixtures of pseudopeptides and metal ions. To obtain additional information on the molecular association, the gel samples were left dry in the air to form xerogels that were further analyzed using SEM and XRD. The formation of gel containing Zn(II) or Cu(II) ions gave good results in term of incorporation of the metal ions, while the presence of Cu(I), Al(III) and Mg(II) gave less satisfactory results. This outcome is a first insight in the formation of stable LMWGs formed by stoichiometric mixtures of pseudopeptides and metal ions. Further studies will be carried out to develop similar compounds of pharmacological interest.
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