Journal
PLANTA MEDICA
Volume 73, Issue 14, Pages 1469-1474Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2007-990244
Keywords
Sonoran propolis; anti proliferative activity; chemical composition
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In this study, we have analyzed the chemical composition and antiproliferative activity of propolis from three different and and semiarid regions of Sonora, Mexico. We identified and quantitated the main chemical constituents of propolis by HPLC-MS. The most abundant constituents of propolis were pinocembrin, pinobanksin 3-acetate, and chrysin. Sonoran propolis had a strong antiproliferative activity on both murine and human cancer cell lines in a concentration-dependent manner. The propolis constituents CAPE, galangin, xanthomicrol and chrysin showed significant antiproliferative activity on most of the cancer cells tested. DNA harvested from cancer cell cultures treated with Sonoran propolis exhibited a ladder of internucleosomal DNA cleavage characteristic of apoptosis. In summary, we have identified and quantitated the main constituents of Sonoran propolis. These propolis samples possess a strong antiproliferative activity on cancer cell lines.
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