Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 35, Issue -, Pages 1205-1207Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0351205
Keywords
diabetes; double-stranded-RNA-dependent protein kinase (PKR)-like ER kinase (PERK); endoplasmic reticulum stress; eukaryotic initiation factor-2 alpha (elF2 alpha); pancreatic beta-cell; unfolded protein response
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Funding
- Wellcome Trust Funding Source: Medline
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To ensure cellular survival to ER (endoplasmic reticulum) stress, PERK [PKR (double-stranded-RNA-dependent protein kinase)-like ER kinase], an ER transmembrane kinase, is activated as part of the unfolded protein response. PERK is highly expressed in pancreatic beta-cells and is essential in the beta-cell's development, differentiation and function. However, chronic activation of PERK can induce cell death, and its activation has been implicated in both Type 1 and Type 2 diabetes. This short review aims to provide an insight into our current understanding of the role of PERK in the life and death of the beta-cell.
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