Journal
CHEMISTRY OF NATURAL COMPOUNDS
Volume 43, Issue 6, Pages 655-658Publisher
SPRINGER
DOI: 10.1007/s10600-007-0221-z
Keywords
mangrove endophytic fungus; isocoumarin; metabolites
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A new isocoumarin, 3,4-dihydro-6-methoxy-8-hydroxy-3,4,5-trimethylisocoumarin-7-carboxylic acid methyl ester (1), together with three known compounds, 3,4-dihydro-4,8-dihydroxy-3,5-dimethylisocoumarin (2), 3,4-dihydro-8-hydroxy-3-methylisocoumarin-5-carboxylic acid (3), and Entinclole SB (4) were isolated from the mangrove endophytic fungus (No. dz17). The structure of the compound 1 was elucidated by analysis of spectroscopic data. Primary bioassays showed that 1 exhibited weak cytotoxicity against Hep-2 and HepG2 cells.
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