Journal
AMINO ACIDS
Volume 40, Issue 5, Pages 1385-1396Publisher
SPRINGER WIEN
DOI: 10.1007/s00726-011-0875-5
Keywords
Creatine; Oxidative stress; Antioxidant; Cytotoxicity; Genotoxicity; Differentiation
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Creatine monohydrate (Cr), the most diffuse supplement in the sports industry, is receiving greater attention because of its beneficial effects in a wide number of human degenerative diseases and conditions. These effects can be barely explained on the basis of the sole ergogenic role of the Cr/CrP system. Indeed, a wide number of research articles indicate that Cr is capable of exerting multiple, non-energy related, effects on diverse and relevant cellular targets. Among these effects, the antioxidant activity of Cr emerges as an additional mechanism which is likely to play a supportive role in the Cr-cytoprotection paradigm.
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