Journal
NEUROCHEMICAL RESEARCH
Volume 32, Issue 11, Pages 1927-1931Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-007-9382-1
Keywords
TGF-beta 1; Golgi apparatus (GA); gerbils
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Golgi apparatus (GA) is a very important organelle involved in the metabolism of numerous proteins. TGF-beta 1 plays an important role in supporting neuronal survival after ischemic insults. Little is known, however, about the morphological alteration of GA and subcellular compartmentalization of TGF-beta 1 in brain after ischemia. Therefore, our present study was designed to check for GA morphological alterations and TGF-beta 1 subcellular localization. GA immunoreactivities were examined in the somatosensory cortex of gerbils after 10 min transient forebrain ischemia. Confocal Immunofluorographs of TGF-beta 1 and TGN38 were also taken. Results indicated that no fragmentation of GA was found in gerbils of norm, shams and 6, 24 and 72 h postocclusion, but some of the cortical cells showed fragmentation of GA in gerbils 7 days postocclusion. TGF-beta 1 was colocalized with TGN38, a marker molecule for the GA. We conclude that there was morphological alterations of GA and TGF-beta 1 was present in GA in the somatosensory cortex after 10 min ischemia.
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