Journal
AMINO ACIDS
Volume 42, Issue 6, Pages 2507-2512Publisher
SPRINGER
DOI: 10.1007/s00726-011-0981-4
Keywords
Glutamine; Glutamine synthetase; Methionine sulfoximine; Phosphinothricin; mTOR
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Funding
- University of Parma Medical School
- Doctorate School of Molecular Medicine, University of Milan
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L-Methionine sulfoximine (MSO) and DL-Phosphinothricin (PPT), two non-proteinogenic amino acids known as inhibitors of Glutamine Synthetase, cause a dose-dependent increase in the phosphorylation of the mTOR substrate S6 kinase 1. The effect is particularly evident in glutamine-depleted cells, where mTOR activity is very low, but is detectable for PPT also in the presence of glutamine. The stimulation of mTOR activity by either MSO or PPT is strongly synergized by essential amino acids. Thus, the non-proteinogenic amino acids MSO and PPT are mTOR activators.
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