Journal
PHARMACOTHERAPY
Volume 27, Issue 11, Pages 1529-1549Publisher
WILEY
DOI: 10.1592/phco.27.11.1529
Keywords
plasma exchange; plasmapheresis; drug removal; pharmacokinetics; apheresis
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Contrary to the literature about drug removal during hemodialysis, data regarding drug removal during plasmapheresis are sparse. Over the last 40 years, approximately 70 publications-mostly case reports of overdoses-have described the effects of plasmapheresis on pharmaceutical agents. Important issues are drug extraction during plasma exchange with chemotherapy, as well as drug classes such as antiinfectives, anticoagulants, antiepileptics, cardiovascular agents, and immunosuppressants. Other considerations are the merits and pitfalls of the different methods used in published reports and recommendations for future pharmacokinetic studies in this field.
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