Journal
PROGRESS IN POLYMER SCIENCE
Volume 32, Issue 11, Pages 1239-1274Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.progpolymsci.2007.05.019
Keywords
gene delivery; cationic polymers; nonviral carriers; polylexes
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Funding
- National Research Foundation of Korea [2006-08301, R0A-2006-000-10228-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In the post genomic era, massive genetic information of the human being accelerates the identification of target genes for treating various diseases. A wide range of nucleic acid therapeutics have recently emerged as powerful new drug entities for treatment of gene-related diseases and for lead validation in the drug discovery process. The absence of an efficient delivery system for genetic drugs has been identified as a major hurdle for clinical applications. Various bio-mimicking polymers have been considered as potential nonviral carriers for gene therapy due to their safety in clinical use, despite their lower gene-transduction capacity compared to virus-based gene carriers that hold risk of potential immunogenicity and endogenous virus recombination. Improving specificity toward target cells and intracellular gene-transferring efficiency will be a prerequisite for successful clinical application of polymeric gene carriers. Multifunctional polymeric gene delivery carriers should be rationally designed at the molecular level for effective human gene therapy. (C) 2007 Published by Elsevier Ltd.
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