Journal
AMINO ACIDS
Volume 40, Issue 1, Pages 15-28Publisher
SPRINGER WIEN
DOI: 10.1007/s00726-010-0516-4
Keywords
Drug discovery; Animal venoms; Venomics; Venom peptides; Natural products
Categories
Funding
- Australian Research Council [DP0774245, DP0878450]
- Australian National Health & Medical Research Council [511067, 569927]
- Senior Research Fellowship
- Australian Biomedical Training Fellowship
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The remarkable potency and pharmacological diversity of animal venoms has made them an increasingly valuable source of lead molecules for drug and insecticide discovery. Nevertheless, most of the chemical diversity encoded within these venoms remains uncharacterized, despite decades of research, in part because of the small quantities of venom available. However, recent advances in the miniaturization of bioassays and improvements in the sensitivity of mass spectrometry and NMR spectroscopy have allowed unprecedented access to the molecular diversity of animal venoms. Here, we discuss these technological developments in the context of establishing a high-throughput pipeline for venoms-based drug discovery.
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