Journal
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
Volume 36, Issue 8, Pages 849-860Publisher
SPRINGER
DOI: 10.1007/s00249-007-0214-7
Keywords
signal transduction; protein interactions; membrane domain; cytoskeleton; FRAP; SPT
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G-protein-coupled receptor function involves interactions between the receptor, G-proteins and effectors in the cell plasma membrane. The main biochemical processes have been individually identified but the mechanisms governing the successive protein-protein interactions of this complex multi-molecular machinery have yet to be established. We discuss advances in understanding the functional dynamics of the receptor resulting from diffusion measurements, and in the context of the plasma membrane organization.
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