Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 191, Issue 1-2, Pages 70-78Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2007.09.018
Keywords
multiple sclerosis; Tr1 regulatory T cells; IL-10; CD46
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Funding
- NIAID NIH HHS [P01 AI039671-05, P01 AI039671] Funding Source: Medline
- NINDS NIH HHS [P01 NS038037, R01 NS024247-10A2, R01 NS024247, P01 NS038037-01A10003] Funding Source: Medline
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Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). In the recent years, accumulating evidence has supported an immunosuppressive role for regulatory T cells (Tregs). Most studies in the context of autoimmunity have focused on the defects of the CD4(+)CD25(high) Tregs. However, we recently demonstrated an altered function of Tr1 Treg cells in MS, characterized by a lack of IL-10 secretion. Therefore, several major regulatory T cell defects are involved in human autoimmune disease. Hence, the induction of Tregs or the stimulation of Treg activity may be beneficial for the treatment of such diseases. (c) 2007 Elsevier B.V. All rights reserved.
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