Journal
PHARMACOLOGICAL RESEARCH
Volume 56, Issue 5, Pages 367-381Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2007.09.006
Keywords
endocannabinoid system; pharmacology; mutant mice; CB1 receptors; endocannabinoids; anxiety; multivariate analysis; fear; extinction; amygdala; GABA; glutamate; circuits
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The endocannabinoid system recently emerged as an important modulator of many neuronal functions. Among them, the control of anxiety and acquired fear represents nowadays one of the most interesting fields of research. Despite contrasting results obtained by the use of cannabinoid receptor agonists in experimental animals, there is growing evidence that the physiological activation of the endocannabinoid system plays a central role in the control of basal anxiety levels and in the modulation of fear responses. This review will summarise recent data on the role of the endocannabinoid system in most commonly used tests of anxiety and in the processing of acquired fear, with particular attention to its involvement in fear extinction. Finally, a neurobiological model possibly able to implement the role of the endocannabinoid system in these processes will be proposed. (c) 2007 Elsevier Ltd. All rights reserved.
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