Journal
TRENDS IN GENETICS
Volume 23, Issue 11, Pages 531-533Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2007.07.007
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Funding
- NIA NIH HHS [R01 AG019206, R01 AG031153] Funding Source: Medline
- NINDS NIH HHS [NS 045016, R01 NS041669, NS 36232, R01 NS045016, R01 NS036232] Funding Source: Medline
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Huntington disease is caused by polyglutamine expansion in huntingtin, a 350 kD protein that is ubiquitously expressed and widely distributed at the subcellular level. Recently, Kaltenbach et al. identified a large collection of novel huntingtin-interacting proteins, several of which modify mutant huntingtin toxicity in Drosophila. Thus, the interaction of mutant huntingtin with certain protein partners can influence its toxicity and therefore the severity and/or progression of Huntington disease.
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