Journal
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
Volume 29, Issue 9, Pages 607-617Publisher
PROUS SCIENCE, SAU-THOMSON REUTERS
DOI: 10.1358/mf.2007.29.9.1139054
Keywords
evaluate; function; inhibitor; MDR; mdr1 gene; p-gp; reversal
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Expression of the multidrug resistance (MDR) phenotype is responsible for chemotherapy failure in numerous cancers. Overexpression of mdr1 gene-encoded permeability glycoprotein (P-gp) is known to play a pivotal role in the development of this phenotype. The role of P-gp has been proposed as an important goal in the design of chemotherapy strategies. However, modulation of P-gp activity by chemotherapy has limited possibilities because of toxicity and poor specificity. It? this article, we review the latest advancements in different potential P-gp-mediated MDR reversal mechanisms as well as the methods of evaluating MDR reversal activity, which would be helpful in finding novel MDR reversal agents (or chemosensitizers). (C) 2007 Prous Science. All rights reserved.
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