Journal
NATURE REVIEWS CANCER
Volume 7, Issue 11, Pages 861-869Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2248
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Funding
- Medical Research Council [G0300662B, G0500897] Funding Source: researchfish
- Medical Research Council [G0500897] Funding Source: Medline
- MRC [G0500897] Funding Source: UKRI
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DNA damage responses (DDR) encompass DNA repair and signal transduction pathways that effect cell cycle checkpoint arrest and/or apoptosis. How DDR pathways respond to low levels of DNA damage, including low doses of ionizing radiation, is crucial for assessing environmental cancer risk. It has been assumed that damage-induced cell cycle checkpoints respond to a single double strand break (DSB) but the G2/M checkpoint, which prevents entry into mitosis, has recently been shown to have a defined threshold of 10-20 DSBs. Here, we consider the impact of a negligent G2/M checkpoint on genomic stability and cancer risk.
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