Journal
CURRENT NEUROVASCULAR RESEARCH
Volume 4, Issue 4, Pages 295-302Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156720207782446306
Keywords
amyotrophic lateral sclerosis; diabetes; apoptosis; FOXO3a; FKHRL1; Akt; erythropoietin; neuromuscular disease; oxidative stress; psychiatric; systemic lupus erythematosus; stroke; stem cells
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Funding
- NIEHS NIH HHS [P30 ES006639, P30 ES06639] Funding Source: Medline
- NINDS NIH HHS [R01 NS053946-02, R01 NS053946, R01 NS053946-01A2] Funding Source: Medline
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The Forkhead transcription factor FOXO3a has emerged as a versatile target for diseases that impact upon neuronal survival, vascular integrity, immune function, and cellular metabolism. Enthusiasm is high to fill a critical treatment void through FOXO3a signaling for several neurodegenerative disorders that include aging, neuromuscular disease, systemic lupus crythematosus, stroke, and diabetic complications. Here we discuss the influence of FOXO3a upon cell survival and longevity, the intricate signal transduction pathways of FOXO3a, insights into present disease models, and the potential clinical translation of FOXO3a signaling into novel therapeutic strategies.
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