Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 35, Issue -, Pages 1358-1363Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0351358
Keywords
biomarker; chemoprevention; indole; plasma profiling; polyphenol; tumour subtype
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Funding
- Medical Research Council [G0100872] Funding Source: Medline
- Medical Research Council [G0100872] Funding Source: researchfish
- MRC [G0100872] Funding Source: UKRI
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Accumulating data suggest that dietary phytochemicals have the potential to moderate deregulated signalling or reinstate checkpoint pathways and apoptosis in damaged cells, while having minimal impact on healthy cells. These are ideal characteristics for chemopreventive and combination anticancer strategies, warranting substantial research effort into harnessing the biological activities of these agents in disease prevention and treatment. However, this requires further investigation into their mode of action and novel approaches to the development of reliable biomarkers.
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