Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 35, Issue -, Pages 1161-1162Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0351161
Keywords
adhesion; endothelial cell; fibroblast; leucocyte; neutrophil; stromal cell
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Funding
- Medical Research Council [G116/131, G9818340] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- MRC [G116/131, G9818340] Funding Source: UKRI
- Medical Research Council [G9818340, G116/131] Funding Source: researchfish
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Vascular endothelial cells play a pivotal role in regulating leucocyte recruitment during inflammation, and their responses can be modulated by their local environment, including cells of the tissue stroma. We have developed a model system to examine how the communication between endothelial cells and fibroblasts regulates the recruitment of leucocytes and their subsequent subendothelial fate. Here, we describe a novel co-culture filter-based flow assay and highlight the ability of synovial fibroblasts obtained from chronically inflamed tissue to promote leucocyte recruitment to otherwise 'resting' endothelial cells.
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