Journal
LARYNGO-RHINO-OTOLOGIE
Volume 86, Issue 11, Pages 804-808Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2007-966932
Keywords
angioedema; ACE-inhibitor; bradykinin; laryngeal edema
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ACE-inhibitor induced angioedema is a non-allergic drug-related side effect. Inhibited bradykinin degradation leads to an unphysiological enhanced bradykinin plasma level with vascular leakage and, consequently, to angioedema. ACE-inhibitor induced angioedema develop rapidly in the head and neck region. Typical sites of manifestation are lips, tongue, and larynx. Novel pharmacotherapies may allow a causal treatment of the ACE-inhibitor induced angioedema in the future.
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