Journal
WIENER KLINISCHE WOCHENSCHRIFT
Volume 119, Issue 19-20, Pages 602-608Publisher
SPRINGER WIEN
DOI: 10.1007/s00508-007-0883-3
Keywords
MEN1; gastrinoma; ZES; surgery
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Gastrinoma is the most frequent functional pancreatioduodenal endocrine tumor in patients with multilpe endocrine neoplasia type 1 (MEN1) and one major determinant of mortality in this syndrome. Whether routine surgical exploration should be performed in a patient with MEN1 associated Zollinger-Ellison syndrome (ZES) to possibly reduce the malignant spread and eventually increase survival still remains controversial. There is not only disagreement about the indication for surgical exploration, but also what type of procedure should be performed, since sufficient evidence-based data are not available. The article discusses the available data on treatment strategies of MEN1 associated ZES.
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