Journal
NATURE NEUROSCIENCE
Volume 10, Issue 11, Pages 1401-1403Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1973
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- NIA NIH HHS [AG19957-06] Funding Source: Medline
- NIMH NIH HHS [R01 MH059970-06, R01 MH059970-07, R01 MH059970-05] Funding Source: Medline
- PHS HHS [59970] Funding Source: Medline
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The hippocampus is often considered to be an important site for stress and learning interactions; however, it has never been demonstrated whether these effects require the hippocampus. In the current study, hippocampal lesions prevented both enhancements of learning after stress in male rats and impairments of learning after stress in female rats without disrupting learning itself in either sex. Thus, the hippocampus is necessary for modifying learning in males and females after acute stressful experience.
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