Journal
ANNALS OF NEUROLOGY
Volume 62, Issue 5, Pages 515-520Publisher
WILEY-LISS
DOI: 10.1002/ana.21214
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Funding
- NIMH NIH HHS [MH071472] Funding Source: Medline
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The effects of cancer treatments such as cranial radiation and chemotherapy on human hippocampal neurogenesis remain unknown. In this study, we examine neuropathological markers of neurogenesis and inflammation in the human hippocampus after treatment for acute myelogenous leukemia or medulloblasroma. We demonstrate a persistent radiation-induced microglial inflammation that is accompanied by nearly complete inhibition of neurogenesis after cancer treatment. These findings are consistent with preclinical animal studies and suggest potential therapeutic strategies.
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