Journal
NATURE REVIEWS CANCER
Volume 7, Issue 11, Pages 847-859Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2223
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Funding
- Biotechnology and Biological Sciences Research Council [BBS/B/03785] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BBS/B/03785] Funding Source: researchfish
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Forkhead box (Fox) proteins are a superfamily of evolutionarily conserved transcriptional regulators, which control a wide spectrum of biological processes. As a consequence, a loss or gain of Fox function can alter cell fate and promote tumorigenesis as well as cancer progression. Here we discuss the evidence that the deregulation of Fox family transcription factors has a crucial role in the development and progression of cancer, and evaluate the emerging role of Fox proteins as direct and indirect targets for therapeutic intervention, as well as biomarkers for predicting and monitoring treatment responses.
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