Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 114, Issue 11, Pages 1425-1431Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-007-0750-4
Keywords
kainate receptors; metabotropic glutamate receptors; presynaptic inhibition; long-term depression; mossy fiber-CA3 synapse; protein kinase A
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Kainate receptors (KARs) effect depression of glutamate release at hippocampal mossy fiber-CA3 (MF-CA3) synapses by a metabotropic action involving adenylyl cyclase (AC) inhibition, cAMP reduction, and diminished protein kinase A (PKA) activation. Using hippocampal slices, we show here that KAR activation interferes with the depression of glutamate release produced by Group II metabotropic glutamate receptor stimulation and low frequency stimulation (LFS)-induced long-term depression (LTD), also expressed through presynaptic AC/cAMP/PKA at MF-CA3 synapses. The mutual occlusion of depression mediated by presynaptic KARs, Group II mGluR and LFS-induced LTD suggests their mechanistic convergence at the MF-CA3 synapse and thus invokes KARs in synaptic plasticity manifest in LTD.
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