Journal
AMERICAN NATURALIST
Volume 184, Issue 2, Pages 172-187Publisher
UNIV CHICAGO PRESS
DOI: 10.1086/676854
Keywords
pathogen reservoir; pathogen transmission; disease tolerance; disease resistance; host developmental tempo; structural equation modeling
Categories
Funding
- National Science Foundation (NSF) [DEB-0923671, DEB-1015909]
- NSF Graduate Research Fellowship
- NSF Postdoctoral Research Fellowship in Biology [DBI-1202676]
- Direct For Biological Sciences
- Division Of Environmental Biology [1015805, 1015825, 1015909] Funding Source: National Science Foundation
- Division Of Environmental Biology
- Direct For Biological Sciences [1015791] Funding Source: National Science Foundation
- Div Of Biological Infrastructure
- Direct For Biological Sciences [1202676] Funding Source: National Science Foundation
Ask authors/readers for more resources
Primary axes of host developmental tempo (HDT; e.g., slow-quick return continuum) represent latent biological processes and are increasingly used to a priori identify hosts that contribute disproportionately more to pathogen transmission. The influence of HDT on host contributions to transmission depends on how HDT influences both resistance and tolerance of disease. Here, we use structural equation modeling to address known limitations of conventional measures of resistance and tolerance. We first provide a general resistance-tolerance metamodel from which system-specific models can be derived. We then develop a model specific to a group of vector-transmitted viruses that infect hundreds of grass species worldwide. We tested the model using experimental inoculations of six phylogenetically paired grass species. We found that (1) host traits covaried according to a prominent HDT axis, the slow-quick continuum; (2) infection caused a greater reduction in the performance of quick returns, with >80% of that greater impact explained by lesser resistance; (3) resistance-tolerance trade-off did not occur; and (4) phylogenetic control was necessary to measure the slow-quick continuum, resistance, and tolerance. These results support the conclusion that HDT's main influence on host contributions to transmission is via resistance. More broadly, this study provides a framework for quantifying HDT's influence on host contributions to transmission.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available