Journal
NATURE METHODS
Volume 4, Issue 11, Pages 907-909Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH1109
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Funding
- NIMH NIH HHS [R01 MH076439-05, R01 MH076439-01, R01 MH076439-02, R01 MH076439-04, R01 MH076439-03, R01 MH076439] Funding Source: Medline
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We developed a general method, microarray-based genomic selection (MGS), capable of selecting and enriching targeted sequences from complex eukaryotic genomes without the repeat blocking steps necessary for bacterial artificial chromosome (BAC)-based genomic selection. We demonstrate that large human genomic regions, on the order of hundreds of kilobases, can be enriched and resequenced with resequencing arrays. MGS, when combined with a next-generation resequencing technology, can enable large-scale resequencing in singleinvestigator laboratories.
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