Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 9, Issue 11, Pages 2027-2033Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2007.1642
Keywords
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Funding
- NIA NIH HHS [2 PO1 AG 15885, 1 RO1 AG024413] Funding Source: Medline
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Glutaredoxins (GRx) catalyze reversible protein glutathionylation. They are implicated in sulfhydryl homeostasis and regulation of redox signal transduction, controlling various cellular processes like DNA synthesis, defense against oxidative stress, apoptosis signaling, and DNA-binding of transcription factors. Two isoforms of GRx are well characterized in mammals: GRx1, the cytosolic form, and GRx2, the mitochondrial form. Here we report documentation of GRx1 in mitochondria, localized exclusively in the intermembrane space and segregated from GRx2, localized exclusively in the mitochondrial matrix. We hypothesize that GRx1 and GRx2 in their unique locations regulate different functions of the mitochondria via reversible S-glutathionylation.
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