Journal
METHODS
Volume 43, Issue 3, Pages 207-217Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymeth.2007.06.004
Keywords
scavenger receptors; endogenous ligand; molecular chaperones; antigen presentation; atherosclerosis; Alzheimer's disease
Funding
- MRC [G0500623] Funding Source: UKRI
- Medical Research Council [G0500623] Funding Source: researchfish
- Medical Research Council [G0500623] Funding Source: Medline
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The scavenger receptors are a large family of molecules that are structurally diverse and have been implicated in a range of functions. They are expressed by myeloid cells, selected endothelial cells and some epithelial cells and recognise many different ligands, including microbial pathogens as well as endogenous and modified host-derived molecules. This review will focus on the eight classes of scavenger receptors (class A-H) in terms of their structure, expression and recognition of host-derived ligands. Scavenger receptors have been implicated in a range of physiological and pathological processes, such as atherosclerosis and Alzheimer's disease, and function in adhesion and tissue maintenance. More recently, some of the scavenger receptors have been shown to mediate binding and endocytosis of chaperone proteins, such as the heat shock proteins, thereby playing an important role in antigen cross-presentation. (C) 2007 Elsevier Inc. All rights reserved.
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