Synthesis, spectral studies and antibacterial activity of novel macrocyclic Co(II) compounds

Ten novel macrocyclic Co(II) compounds have been synthesized by treating four N-4 and six N2O2 donor macrocycles with cobalt chloride in methanol. These compounds were characterized by elemental, IR, H-1, C-13 NMR, mass, electronic spectral analysis, molar conductance and magnetic susceptibility measurements. Thermal behavior of these compounds has been studied by the thermogravimetric analysis. An octahedral geometry has been proposed for all of these complexes. All the macrocycles and macrocyclic Co(II) compounds along with existing antibacterial drugs were screened for antibacterial activity against Gram +ve and Gram -ve bacteria. All these compounds were found to be more active when compared to streptomycin and ampicillin. (C) 2007 Elsevier B.V. All rights reserved.