Journal
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volume 37, Issue 13, Pages 1491-1500Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ijpara.2007.05.004
Keywords
age-prevalence prediction; Bayesian statistics; immigration-death model; Kato-Katz technique; schistosomiasis; Schistosoma mansoni
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Funding
- Wellcome Trust [071657] Funding Source: Medline
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Models that accurately estimate the age-specific infection prevalence of Schistosoma mansoni can be useful for schistosomiasis control programmes, particularly with regard to whether mass drug administration or selected treatment should be employed. We developed a Bayesian formulation of an immigration-death model that has been previously proposed, which used maximum likelihood inference for estimating the age-specific S. mansoni prevalence in a dataset from Egypt. For comparative purposes, we first applied the Bayesian formulation of the immigration-death model to the dataset from Egypt. We further analysed data obtained from a cross-sectional parasitological survey that determined the infection prevalence of S. mansoni among 447 individuals in a village in Cote d'Ivoire. Three consecutive stool samples were collected from each participant and analysed by the Kato-Katz technique. In the Cote d'Ivoire study, the observed S. mansoni infection prevalence was 41.6% and varied with age. The immigration-death model was able to correctly predict 50% of the observed age group-specific point prevalences. The model presented here can be utilized to estimate S. mansoni community infection prevalences, which in turn helps in the strategic planning of schistosomiasis control. (c) 2007 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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