Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 28, Issue 11, Pages 551-555Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2007.10.001
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There is strong evidence for the existence of Gq/11-coupled dopamine receptors in the brain but the mechanism by which dopamine signaling activates Gq/11, or its roles in neuronal function, are only just beginning to be understood. The importance of such a pathway is underlined by putative links between dopamine-regulated phosphoinositide signaling and several central nervous system disorders that include schizophrenia, addiction and Parkinson's disease.
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