Journal
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
Volume 22, Issue 6, Pages 589-601Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911507084653
Keywords
drug delivery; hydrogel; biodegradable; PEG; schiff base; doxorubicin
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In our quest to develop new drug delivery systems, we designed and synthesized PEG-conjugates and PEG-hydrogels with a degradable linkage to the drug. Specifically, methoxyPEG-doxorubicin (MPEG-CH = N-Doxo) and doxorubicin-PEG aldehyde (OHC-PEG-CH = N-Doxo) conjugates, plus poly (vinyl amine)-PEG-doxorubicin (PVAm-PEG-Doxo) hydrogels were prepared. The hydrogels were crosslinked by PEG-Schiff base linkages, and the Doxo was conjugated to the gel by pendant Schiff base bonds (PVAm-N = CH-PEG-CH = N-Doxo). The release profile of Doxo from the hydrogels was dependent on pH and on the ratio of PVAm to the PEG-dialdehyde crosslinker. These degradable PEG hydrogels could be good candidates for slow release of Doxo from subcutaneous or IM implants.
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