Journal
JOURNAL OF DENTAL RESEARCH
Volume 86, Issue 11, Pages 1013-1021Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/154405910708601101
Keywords
bone; bisphosphonate; BRONJ; mandible; osteonecrosis; osteoporosis; jaw
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Bisphosphonates are a class of agents used to treat osteoporosis and malignant bone metastases. The efficacy of these agents in treating and preventing the significant skeletal complications associated with these conditions has had a major positive impact for patients and is responsible for their widespread use in medicine. Despite these benefits, osteonecrosis of the jaws has recently emerged as a significant complication in a subset of patients receiving these drugs. Based on a growing number of case reports and institutional reviews, bisphosphonate therapy may cause exposed and necrotic bone that is isolated to the jaw. This complication usually presents following simple dento-alveolar surgery, and can cause a significant adverse effect on the quality of life for most patients. The pathogenesis for this complication appears to be related to the profound inhibition of osteoclast function and bone remodeling.
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