Journal
JOURNAL OF AFFECTIVE DISORDERS
Volume 103, Issue 1-3, Pages 113-120Publisher
ELSEVIER
DOI: 10.1016/j.jad.2007.01.015
Keywords
anxiety; depression; cross-sectional; chronic conditions
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Funding
- FIC NIH HHS [R01-TW006481] Funding Source: Medline
- NIDA NIH HHS [R01 DA016558] Funding Source: Medline
- NIMH NIH HHS [R01-MH059575, R01-MH069864, U01-MH60220, R01-MH61905, R01MH070884, R13-MH066849] Funding Source: Medline
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Background: Prior research on the association between affective disorders and physical conditions has been carried out in developed countries, usually in clinical populations, on a limited range of mental disorders and physical conditions, and has seldom taken into account the comorbidity between depressive and anxiety disorders. Methods: Eighteen general population surveys were carried out among adults in 17 countries as part of the World Mental Health Surveys initiative (N=42, 249). DSM-IV depressive and anxiety disorders were assessed using face-to-face interviews with the Composite International Diagnostic Interview (CIDI 3.0). Chronic physical conditions were ascertained via a standard checklist. The relationship between mental disorders and physical conditions was assessed by considering depressive and anxiety disorders independently (depression without anxiety; anxiety without depression) and conjointly (depression plus anxiety). Results: All physical conditions were significantly associated with depressive and/or anxiety disorders but there was variation in the strength of association (ORs 1.2-4.5). Non-comorbid depressive and anxiety disorders were associated in equal degree with physical conditions. Comorbid depressive-anxiety disorder was more strongly associated with several physical conditions than were single mental disorders. Limitations: Physical conditions were ascertained via self report, though for a number of conditions this was self-report of diagnosis by a physician. Conclusions: Given the prevalence and clinical consequences of the co-occurrence of mental and physical disorders, attention to their comorbidity should remain a clinical and research priority. (C) 2007 Elsevier B.V. All rights reserved.
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