Journal
NEUROBIOLOGY OF AGING
Volume 28, Issue 11, Pages 1789-1790Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2006.07.016
Keywords
CHMP2B; POU1F1; frontotemporal dementia; genetic analysis; association study
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Mutations of the chromatin modifying protein 213 gene (CHMP2B) were identified, in a Danish pedigree, to cause familial frontotemporal dementia (FTD). To explore the possible genetic contribution of common CHMP2B variants in sporadic FFD, we analyzed 14 single nucleotide polymorphisms covering the entire genomic region of CHMP2B. After adjustment for multiple testing single marker and haplotype analysis revealed no significant association with sporadic FTD. Thus, we conclude that CHMP2B can be excluded as a susceptibility gene conferring risk to sporadic forms of FTD. (c) 2006 Elsevier Inc. All rights reserved.
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