Journal
PLOS GENETICS
Volume 3, Issue 11, Pages 2037-2048Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.0030199
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Funding
- NIDDK NIH HHS [K08 DK078605, K08 DK078605-02, P30 DK063720, K08-DK078605] Funding Source: Medline
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A pandemic of metabolic diseases (atherosclerosis, diabetes mellitus, and obesity), unleashed by multiple social and economic factors beyond the control of most individuals, threatens to diminish human life span for the first time in the modern era. Given the redundancy and inherent complexity of processes regulating the uptake, transport, catabolism, and synthesis of nutrients, magic bullets to target these diseases will be hard to find. Recent studies using the worm Caenorhabditis elegans, the fly Drosophila melanogaster, and the zebrafish Danio rerio indicate that these ''lower'' metazoans possess unique attributes that should help in identifying, investigating, and even validating new pharmaceutical targets for these diseases. We summarize findings in these organisms that shed light on highly conserved pathways of energy homeostasis.
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