Journal
IEEE SENSORS JOURNAL
Volume 7, Issue 11-12, Pages 1680-1684Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSEN.2007.909230
Keywords
biosensor; impedance; interdigitated capacitors; nanogap; prostate specific antigen (PSA)
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Nanogap impedance biosensors with an electrode separation of 75 nm have been used for the specific detection of biological interactions. Different model systems, such as thrombin-anti-thrombin antibody, and Rev-peptide-anti-Rev aptamer are presented to demonstrate the detectability of different molecular masses at varying concentrations. In order to improve the signal-to-noise ratio, the use of reference sensors has been explored. The interaction of prostate specific antigen (PSA) with an anti-PSA antibody is shown to demonstrate the detection at concentrations as low as 10 nM.
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