Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 17, Issue 21, Pages 5740-5743Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.08.070
Keywords
T-type calcium channel; 3,4-dihydroquinazoline; kurtoxin; blocker
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Funding
- National Research Foundation of Korea [2006-06931, 핵06A3002] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The intensive SAR study of 3,.4-dihydroquinazoline series led to the most potent compound 10 (KYS05090: IC50 = 41 +/- 1 nM) against T-type calcium channel and its potency is nearly comparable to that of Kurtoxin. As a small organic molecule, this compound showed the highest blocking activity reported to date. (c) 2007 Elsevier Ltd. All rights reserved.
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