Journal
CANCER JOURNAL
Volume 13, Issue 6, Pages 345-348Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PPO.0b013e31815a7b69
Keywords
tumor; angiogenesis; vascular endothelial growth factor (VEGF); VEGF receptor-1; VEGF receptor-2
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The identification and characterization of several important regulators of angiogenesis, which led to Food and Drug Administration approval of the first antiangiogenic drugs, has opened a new era in cancer therapy. This article focuses on the clinical progress in targeting one of the major regulators of angiogenesis, vascular endothelial growth factor-A and also discusses some recent advances in the elucidation of potential cellular and molecular mechanisms underlying refiractoriness or resistance to antiangiogenic therapies.
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