Journal
NATURE REVIEWS GENETICS
Volume 8, Issue 11, Pages 829-833Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2218
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Funding
- NIGMS NIH HHS [GM071004] Funding Source: Medline
- PHS HHS [NCI118487] Funding Source: Medline
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The discovery of an increasing number of histone demethylases has highlighted the dynamic nature of the regulation of histone methylation, a key chromatin modification that is involved in eukaryotic genome and gene regulation. A flurry of recent studies has offered glimpses into the specific biological roles of these enzymes and their potential connections to human diseases. These advances have also catalysed a resurgence of interest in epigenetic regulators as potential therapeutic targets.
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