Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 18, Issue 9, Pages 350-355Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2007.08.008
Keywords
-
Categories
Funding
- NHLBI NIH HHS [HL51298, HL39226, HL56249, HL64180] Funding Source: Medline
Ask authors/readers for more resources
The oxygen required to meet metabolic needs of all tissues is delivered by the erythrocyte, a small, flexible cell which, in mammals, is devoid of a nucleus and mitochondria. Despite its simple appearance, this 'bag of hemoglobin' has an important role in its own distribution, enabling the delivery of oxygen to precisely meet localized metabolic need. When an erythrocyte enters an area in which tissue oxygen demand exceeds supply, a signaling pathway is activated resulting in the release of adenosine 5'-triphosphate (ATP). This ATP acts in a paracrine fashion to increase vascular caliber resulting in increased oxygen delivery. Defects in this pathway are found in erythrocytes of humans with type 2 diabetes (DM2) and could contribute to the perfusion abnormalities in skeletal muscle associated with this disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available