Journal
NANO LETTERS
Volume 7, Issue 11, Pages 3405-3409Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl071792z
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Funding
- NIBIB NIH HHS [R01 EB008260, R01 EB008260-01] Funding Source: Medline
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Nanowire field effect transistors (NW-FETs) can serve as ultrasensitive detectors for label-free reagents. The NW-FET sensing mechanism assumes a controlled modification in the local channel electric field created by the binding of charged molecules to the nanowire surface. Careful control of the solution Debye length is critical for unambiguous selective detection of macromolecules. Here we show the appropriate conditions under which the selective binding of macromolecules is accurately sensed with NW-FET sensors.
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