Trichloroisocyanuric acid, a new and efficient catalyst for the synthesis of dihydropyrimidinones

An efficient three-component synthesis of 3,4-dihydropyrimidinones using trichloroisocyanuric acid (TCCA) as a mild, homogeneous and neutral catalyst for Biginelli reaction in ethanol or DMF under reflux condition and microwave irradiation is described. Yields are excellent in either of the two conditions. (c) 2007 Elsevier B.V. All rights reserved.