Journal
MOLECULAR IMAGING
Volume 6, Issue 6, Pages 384-392Publisher
SAGE PUBLICATIONS INC
DOI: 10.2310/7290.2007.00034
Keywords
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Funding
- NIBIB NIH HHS [R21 EB005325-03, R21 EB005325, R21 EB005325-01, R21 EB005325-02] Funding Source: Medline
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Encapsulated microbubble contrast agents incorporating an adhesion ligand in the microbubble shell are used for molecular imaging with ultrasound. Currently available microbubble agents are produced with techniques that result in a large size variance. Detection of these contrast agents depends on properties related to the microbubble diameter such as resonant frequency, and current ultrasound imaging systems have bandwidth limits that reduce their sensitivity to a polydisperse contrast agent population. For ultrasonic molecular imaging, in which only a limited number of targeted contrast agents may be retained at the site of pathology, it is important to optimize the sensitivity of the imaging system to the entire population of contrast agent. This article presents contrast agents with a narrow size distribution that are targeted for molecular imaging applications. The production of a functionalized, lipid-encapsulated, microbubble contrast agent with a monodisperse population is demonstrated, and we evaluate parameters that influence the size distribution and demonstrate initial acoustic testing.
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